Maine's Western Lakes and Mountains Region is best reached by car via I-95. From points south, travelers should take I-95 north and pick up Route 302 north. From points north, travelers should take I-95 south into Bangor, then follow Route 2 west.
Three US highways which run through the region. Route 302 runs from Fryeburg through Bridgton, Windham, to Portland.
U.S. Route 202 runs northward from the South Coast, passing through Auburn, Lewiston and Leeds before heading into the Kennebec region.
U.S. Route 2 takes an east-west route through Gilead, Bethel, Rumford, Mexico, Wilton, and Farmington. The highway continues on to the east, ending in Bangor.
Routes 27, 16 and 17 pass through Rangely, Stratton, Bigelow, Carrabassett, and Grafton Notch State Park.