Kahtadin Moosehead is directly accessible via I-95, and visitors from points north and south should begin with the Interstate. I-95 passes near to Lincoln, Mattawamkeag and Millinocket, and directly through Medway. It runs only through the southeastern corner of the region.
Maine Routes 11 and 6 will take travelers through the southwestern part of the region, and to Milo, Dover-Foxcroft and up towards Greenville (on Route 6 and 15).
Local roads lead further north, up to Baxter State Park and the whitewater areas near Ripogenus Dam.
Route 11 northward from Millinocket and Medway will take travelers up to Sherman, Patten and Hersey.
From Patten, Route 159 heads north to Shin Pond.